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Fields & Applications Liquid Chromatography, Proteomics, Clinical

Mapping Melanoma

LC-PRM-driven proteomics helps explore the mechanisms behind cancer metastasis

Matthew Hallam | | Quick Read

Targeted quantitative proteomics – using LC-parallel reaction monitoring (PRM) – is shining a light on kinome protein reprogramming during melanoma metastasis. Weili Miao and colleagues found that the expression of Janus kinase 3 (JAK3; a tyrosine kinase) is reduced in metastatic melanoma cells when compared with primary (non-metastatic) cells, by applying LC-MS and LC-MS/MS to tryptic digests.

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Fields & Applications Liquid Chromatography, Proteomics, Clinical

About the Author

Matthew Hallam

I've always wanted a career in which I could practice my creativity, even when I worked on the assembly line in a fish factory. At one time, I channeled this need into dance, drawing, poetry and fiction, and I still do most of these things. But, following completion of my MSc(Res) in Translational Oncology and time working in labs and as a Medical Writer for major pharmaceutical companies, I'm happy to find myself in a career that allows me to combine my creative side with my scientific mind as the Editor of The Analytical Scientist.

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