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Fields & Applications Liquid Chromatography, Proteomics, Clinical

Mapping Melanoma

LC-PRM-driven proteomics helps explore the mechanisms behind cancer metastasis

Matthew Hallam | | Quick Read

Targeted quantitative proteomics – using LC-parallel reaction monitoring (PRM) – is shining a light on kinome protein reprogramming during melanoma metastasis. Weili Miao and colleagues found that the expression of Janus kinase 3 (JAK3; a tyrosine kinase) is reduced in metastatic melanoma cells when compared with primary (non-metastatic) cells, by applying LC-MS and LC-MS/MS to tryptic digests.

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Fields & Applications Liquid Chromatography, Proteomics, Clinical

About the Author

Matthew Hallam

I've always wanted a job that fosters creativity - even when I worked on the assembly line in a fish factory. Outside work, I satisfy this need by writing questionable fiction. The venture into science writing was an unexpected departure from this fiction, but I'm truly grateful for the opportunity to combine my creative side with my scientific mind as Editor of The Analytical Scientist.

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