LC-PRM-driven proteomics helps explore the mechanisms behind cancer metastasis
Matthew Hallam | | Quick Read
Targeted quantitative proteomics – using LC-parallel reaction monitoring (PRM) – is shining a light on kinome protein reprogramming during melanoma metastasis. Weili Miao and colleagues found that the expression of Janus kinase 3 (JAK3; a tyrosine kinase) is reduced in metastatic melanoma cells when compared with primary (non-metastatic) cells, by applying LC-MS and LC-MS/MS to tryptic digests.
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