Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Subscribe to Newsletter
Fields & Applications Liquid Chromatography, Proteomics

Prostate Proteomics

Prostate cancer is the fifth leading cause of death among men in western countries, but identifying high-risk individuals with current diagnostic tools is difficult – in part because of the heterogeneous nature of the disease. Although a number of studies have looked at genomic and transcriptomic alterations in prostate cancer, they have not previously been linked to changes at the proteome level.

With a plan to connect the dots, a team of researchers assessed key changes in PCa tissue during tumor progression (1). Using a combination of proteomics and transcriptomics (LC-MS/MS), tissue-microarray generation, and retrospective data analysis, they found that the expression levels of NDUFS1 and ATP50 genes and associated proteins were significantly higher in PCa patients.

Though more work is needed, the researchers believe that the NDUFS1 and ATP50 proteins may serve as novel prognostic markers for the identification of high-risk PCa patients.

Image Credit: National Cancer Institute, National Institutes of Health

Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. R Wiebringhaus et al., Cancers, 13, 6036 (2021). DOI:  10.3390/cancers13236036
Related Application Notes
Instrumental Analysis to Visualize Differences in Taste

| Contributed by Shimadzu

Analysis of mRNA coupled to enhanced green fluorescent protein by RP and IEX

| Contributed by YMC

Analysis of Aroma for Beverage Quality Control

| Contributed by Shimadzu

Related Product Profiles
The fine Art of Method Development

| Contributed by Shimadzu Europa

Higher Peaks – Clearly.

| Contributed by Shimadzu Europa

Compact with countless benefits

| Contributed by Shimadzu Europa

Most Popular
Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register