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Fields & Applications Liquid Chromatography, Pharma & Biopharma

Taming Biopharma with 2D Separations

In recent years at the Research Institute for Chromatography (RIC), we have noted a remarkable shift in analytical development projects from the pharmaceutical industry. Ten years ago, requests were mainly related to small molecule synthetic drugs, such as the blockbuster atorvastatin (trade name Lipitor from Pfizer) with a formula of C33H35FN2O2 and a molar mass of 559 g/mol. However, today’s demands often involve large recombinantly expressed protein biopharmaceuticals, such as monoclonal antibodies (mAbs) – exemplified by trastuzumab (trade name Herceptin from Roche/Genentech), a highly heterogenous product with a formula of C6560H10132N1728O2090S44 and molar mass 148,057 g/mol for one of its main variants! A big shift indeed.

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About the Author

Pat Sandra and Koen Sandra

Pat Sandra is President and Koen Sandra is Scientific Director at the Research Institute for Chromatography, Belgium.

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