The ‘One Pot’ Approach
Tom Metz, Integrative Omics Scientist and Metabolomics Technical Lead at Pacific Northwest National Laboratory (Washington State, USA), selects six papers that exemplify the power of multi-omics.
Tom Metz |
When people select one technology over another it’s usually because they “grew up with it”, which is either dependent on where they did their PhD work, or which kind of -omics they happened to apply first to their area of biology. So many molecules are detected with -omics technologies that the false positive rate is likely higher than we expect given today’s tools and metrics. When basing subsequent hypotheses and publishing results on single-omic studies, there is bound to be misinformation put forth. Being able to perform additional -omics experiments will help constrain that to some extent. For example, if someone performs a transcriptomic study and has complementary proteomic data (or other -omics data), they will be able to check if what they thought might be going on at the transcript level had propagated through to the protein or the metabolite level.
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