The Rise, Fall and Rise of FFF
Nearly half a century ago, J. Calvin Giddings published a letter that laid out his ideas for a new separation strategy. It resulted in a collection of techniques known as field-flow fractionation (FFF). Here, three analytical scientists at the heart of FFF developments discuss the history, the ups and downs, and the relatively recent resurgence of the technique.
Wim Kok |
AF4’s Time in the Sun?
In 1966, J. Calvin Giddings published “A New Separation Concept Based on a Coupling of Concentration and Flow Nonuniformities” in Separation Science (1). His innovative idea suggested transporting a mixture of different analytes through a thin channel using a laminar (Poiseuille) flow of a carrier solution. If you ‘force’ specific analytes into particular flow lines in the channel, using an external field perpendicular to the flow direction, the differences in velocity between the flow lines will separate the analytes much faster than the field itself.
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