Objective:

To investigate the association between lesser-studied PFAS compounds, specifically PFNA and PFSA, and epigenetic aging in US adults.

Key Findings:

• PFNA and PFSA were detected in about 95% of participants.
• PFNA was most strongly associated with accelerated epigenetic aging, particularly in men and adults aged 50 to 64, as measured by GrimAge-related metrics and other algorithms.
• Other PFAS like PFOA and PFOS showed no significant associations with epigenetic aging.

Interpretation:

The study suggests that PFNA and PFSA may have more significant impacts on aging processes compared to older PFAS compounds, warranting further research.

Limitations:

• The study is based on a specific age group (50 years and older), limiting generalizability.
• Potential confounding factors related to lifestyle, such as smoking and diet, were not fully explored.

Conclusion:

The findings highlight the need to consider newer PFAS compounds in health assessments related to aging, as they may pose unique risks to public health.