A Closer Look at the Bigger Picture
How a pixel-based approach can define the unique chemical fingerprint of a complex environmental sample.
Guilherme L. Alexandrino, Josephine Lübeck and Jan. H. Christensen |
The latest high-throughput and powerful chromatographs and mass analyzers have found their rightful place in analytical laboratories worldwide. These instruments provide an extraordinary amount of high-quality data, especially comprehensive two-dimensional chromatography (for example, GC×GC or LC×LC) and/or high-resolution mass spectrometers.
One rising star in analytical chemistry is the combination of the pixel-based approach with non-targeted analysis. Here, we aim to look at the whole spectrum of chemical compounds in the samples by using the entire chromatogram in the data analysis, instead of individual peak picking and integrations. The great advantage is that the chemical differences between samples is highlighted in a broader way, particularly useful in petroleum and oil characterization, omics-based studies and the analysis of environmental pollution.
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