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Techniques & Tools Mass Spectrometry, Metabolomics & Lipidomics, Clinical, Liquid Chromatography

How To Personalize Medicine

The measurement of individual organic molecules to determine inborn errors of metabolism, diagnose disease and monitor therapy and recovery is not new; indeed, it has a long and illustrious history. Can continuing advances in metabolomics answer growing calls for understanding ‘health’ more deeply and drive personalized medicine development? I believe so.

Molecules that are routinely evaluated in the clinic include testosterone and other hormones; vitamin D3; peptides; classes of compounds related to metabolic function, such as amino acids, organic acids, sugars and acylcarnitines; and many other organic molecules, such as lipids. Yet, there are hundreds, and more likely thousands, of molecules that are routinely ignored, either because a clear association has never been made to genetic variation, disease or well-being, or because they have been too difficult to measure in an affordable multiplexed fashion.

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About the Author

author ian jardine

Ian Jardine

“For the past 25 years, one person has stood out as Thermo Fisher’s greatest champion of innovation,” according to CEO Mark Caspar. That person is Ian Jardine. In presenting Thermo Fisher Scientific’s 2014 Lifetime in Innovation Achievement Award to Jardine, Casper described his “infectious passion for science,” and his “uncanny ability to predict what customers would need long before they knew themselves.”This publication also benefited from that insight: Ian served on the Editorial Advisory Board from pre-launch days up until this issue.

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