How To Personalize Medicine
Two new studies demonstrate the power of advanced metabolomics; progress in instrumentation will propel it into the clinic
Ian Jardine |
The measurement of individual organic molecules to determine inborn errors of metabolism, diagnose disease and monitor therapy and recovery is not new; indeed, it has a long and illustrious history. Can continuing advances in metabolomics answer growing calls for understanding ‘health’ more deeply and drive personalized medicine development? I believe so.
Molecules that are routinely evaluated in the clinic include testosterone and other hormones; vitamin D3; peptides; classes of compounds related to metabolic function, such as amino acids, organic acids, sugars and acylcarnitines; and many other organic molecules, such as lipids. Yet, there are hundreds, and more likely thousands, of molecules that are routinely ignored, either because a clear association has never been made to genetic variation, disease or well-being, or because they have been too difficult to measure in an affordable multiplexed fashion.
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