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Techniques & Tools Liquid Chromatography, Mass Spectrometry, Data Analysis

Is Your Biomarker Analysis Accurate?

Supercritical fluid chromatography (SFC) finally appears ready for prime time with both Agilent and Waters selling viable machines. But, in the bioanalytical field at least, there has been surprisingly little interest shown to date. Might this be due, in part at least, to the fact that chromatography in general has taken a back seat to the selectivity provided by triple sector mass spectrometry(MS) and highly selective antibodies in the case of ligand-binding assays?

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About the Author

James Settlage

James Settlage is Senior Research Investigator at inventive Health, Princeton, New Jersey. Dr Settlage received his bachelor’s degree in chemistry from the University of California at Berkeley and his PhD from the University of California at Davis under the tutelage of the late Professor Walter Jennings. Jimbegan his bioanalytical career in 1981 in bioanalysis at LAB, in Neu Ulm, Germany in 1981, where he was among the first people to introduce GC-MS to the field of bioanalysis. He has since served as the Director of R&D at PPD in Richmond, Virginia, USA, and Vice President of Lab Operations at Taylor Technology, now inventive Health Clinical in Princeton, New Jersey, USA. He has served on FDA advisory panels as an expert bioanalytical scientist and he was also a presenter and participant at the 2001 Crystal City conference on bioanalytical method validation, which was a pivotal point in the history of bioanalysis.

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