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Techniques & Tools Liquid Chromatography, Pharma & Biopharma, Mass Spectrometry, Technology

LC on the Edge

Testing Boundaries, By Davy Guillarme
New Wave, By Koen Sandra
Keep Pushing, By Fabrice Gritti
Up the (R)Evolution!By Gert Desmet
Through the Maze, By Monika Dittmann
2D-LC Has Arrived, By James Jorgenson

Testing Boundaries

Complex biological samples demand a new generation of LC systems

A major breakthrough in LC over the past 10 years has been the commercialization of modern chromatographic systems able to work at pressures up to 1,000–1,500 bar, with low extra-column volume and dwell volume. In parallel, new columns packed with sub 2 μm fully porous particles and sub 3 µm superficially porous particles entered the market. Together, these two innovations have led to a resurgence of interest in HPLC.

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About the Author

Davy Guillarme

Davy Guillarme is Senior Lecturer in the School of Pharmaceutical Sciences, University of Geneva/University of Lausanne, Geneva, Switzerland.

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