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Techniques & Tools Mass Spectrometry, Pharma & Biopharma, Capillary Electrophoresis

Playing the ACE Card in LBAs

Ligand binding assays (LBAs) are indispensable for biological understanding – and to develop new pharmaceuticals. Due to their tremendous importance, LBAs need to be biologically relevant, precise and accurate. Unfortunately, sometimes they are not. In fact, the data obtained often vary so strongly that only variations by orders of magnitude are considered as real changes. This questionable data quality still limits progress in drug discovery.

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  1. S. El Deeb et al., “Recent advances in capillary electrophoretic migration techniques for pharmaceutical analysis”, Electrophoresis, 37, 1591-1608 (2016).
  2. H. A. Alhazmi et al., “A comprehensive platform to investigate protein–metal ion interactions by affinity capillary electrophoresis”, Journal of Pharmaceutical and Biomedical Analysis 107, 311–317 (2015).

About the Author

Hermann Wätzig

Hermann Wätzig studied pharmacy at the Freie Universität Berlin from 1981 to 1985, and in 1989 wrote his PhD thesis on HPLC, supervised by Prof. Dr. S. Ebel. From 1990, he became lecturer at the Institut für Pharmazie in Würzburg and he completed his Habilitation n 1995. In 1999, he was appointed to a professorship in pharmaceutical chemistry at the Technical University of Braunschweig. Since 2001, he has been chair of the division of pharmaceutical analysis/quality control of the German Pharmaceutical Society. He is Editorial Board Member of the journal Electrophoresis, scientific committee member of BfArM, CE Pharm and ISEAC, expert in the European Pharmacopoeia and visiting Professor at Shizuoka Universität.

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