Slip Flow Star
The use of submicrometer particles in chromatography, viewed as heresy when first suggested a decade ago, is today seen as a possible quantum leap in separation efficiency. This is a first‑hand account of the origins of the idea, the experiments that yielded crystal-clear data and the literature on slip flow that provided an explanation of the remarkable findings.
Mary Wirth |
The -omics era has inspired creativity across analytical chemistry by posing interesting new challenges. In my case, the stimulus to think about new materials for separations came at the 1999 Gordon Conference on Analytical Chemistry, which included the emerging field of proteomics. I was taken aback by the images of stained two-dimensional gels, which are riddled with streaks, especially for large proteins, and wondered why no-one commented on these and how they must hide lower abundance proteins. When I asked, people said “that’s just the way it is”. The gel images made me think about what kind of material could enable protein electrophoresis without streaks.
Read the full article now
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.