The Top 10 Game Changers in HPLC History
Progress in any field is expected if not inevitable; as technology advances and as new knowledge is gained, iterative improvements feed a baseline of linear evolution. But there are also often leaps forward – true innovations. Here, we look back on the first 50 years of HPLC instrumentation and select the Top 10 (okay, you got me, a tie made it a Top 11) breakthroughs that paved the way for the technique we know today.
Ron Majors, John Baltrus | | Longer Read
When HPLC was “discovered” over 50 years ago, it revolutionized the field of analytical chemistry. Major developments in the technique – which seemed to occur almost yearly in the 1970s and the early 1980s – ranged from revolutionary to evolutionary. During that period, the technique quickly shifted from a large-particle, gravity-fed, large-bore glass column technique to an automated, small-particle, high-pressure, narrow-bore stainless steel column technique. In the story of HPLC development, the column and the instrument are intertwined – and both have played pivotal roles in increasing separation speed, boosting efficiency, and improving quantitation.
In this article, we attempt to identify – with the help of a panel of LC, data systems and mass spectrometry experts (see “We Couldn’t Have Done It Without You”) – the developments that truly “made a difference.” We believe the resulting Top 10 allowed HPLC to surpass most other techniques in terms of application range and its ability to answer analytical questions. And so, without further ado...
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