Think Fast, Screen Faster
Ten thousand reactions per hour – or else? No problem!
Roisin McGuigan |
Combinatorial chemistry and other procedures have produced large libraries of chemical compounds – the (re)activity of which need to be assessed. High throughput screening (HTS) is already an important component of the drug discovery toolbox, but could it be improved? R. Graham Cooks, Henry B. Hass Distinguished Professor of Analytical Chemistry at Purdue University, Indiana, USA, certainly thinks so.
Cooks’ team has developed an even faster HTS process by coupling desorption electrospray ionization mass spectrometry (DESI-MS) with robotic sampling technologies. “We started with the observation that ordinary organic reactions, carried out in small droplets, are accelerated over bulk rates by several orders of magnitude, depending (inversely) on the size of the droplets – and this is now a well-established phenomenon,” explains Cooks.
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