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Techniques & Tools Genomics & DNA Analysis, Technology, Mass Spectrometry

Think Fast, Screen Faster

Combinatorial chemistry and other procedures have produced large libraries of chemical compounds – the (re)activity of which need to be assessed. High throughput screening (HTS) is already an important component of the drug discovery toolbox, but could it be improved? R. Graham Cooks, Henry B. Hass Distinguished Professor of Analytical Chemistry at Purdue University, Indiana, USA, certainly thinks so.

Cooks’ team has developed an even faster HTS process by coupling desorption electrospray ionization mass spectrometry (DESI-MS) with robotic sampling technologies. “We started with the observation that ordinary organic reactions, carried out in small droplets, are accelerated over bulk rates by several orders of magnitude, depending (inversely) on the size of the droplets – and this is now a well-established phenomenon,” explains Cooks.

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About the Author

Roisin McGuigan

I have an extensive academic background in the life sciences, having studied forensic biology and human medical genetics in my time at Strathclyde and Glasgow Universities. My research, data presentation and bioinformatics skills plus my ‘wet lab’ experience have been a superb grounding for my role as an Associate Editor at Texere Publishing. The job allows me to utilize my hard-learned academic skills and experience in my current position within an exciting and contemporary publishing company.

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