Accurate and fast analysis of human plasma using targeted proteomics
contributed by Biognosys |
Introduction
Blood plasma and serum are the most common sample types in routine diagnostics as well as for biomarker discovery. Levels of blood proteins reflect the health status of single organs and the body as a whole. Changes in composition of proteins in the blood can be directly correlated to disease onset or therapy response.
Monitoring of blood proteins is today mainly performed by immunoassays. However, immunoassays have several limitations like specificity, low multiplexing ability, and its expensive development for new protein targets. These challenges can be overcome by using targeted proteomics, a mass spectrometry based method that allows absolute quantification of more than 100 proteins analyzed in high-throughput mode in thousands of samples.
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