App Notes

Exposure to air pollutants has for many years been recognised as a major cause of health problems.

Aroma profiles of food contain a wide variety of components at a range of concentrations.

Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC×GC–TOF MS) offers greatly enhanced peak capacity

The introduction of environmental legislation, such as the EU Water Framework Directive, has enhanced the requirement for confident identification of contaminants in water.

In most areas of drug discovery & development, drug metabolism, and for degradation studies such as pharmaceuticals and environmental pollutants, there is a severe need for reference materials

The knowledge of the metabolic pathways and the biotransformation of new drugs are crucial for elucidation of degradation routes of the new active compounds, especially in the area of possible toxicity.

Reduction of disulfide bonds in peptides and proteins prior to MS analysis is done for several reasons.

Efficient and fast separation for low molar mass polymers and proteins can be achieved using a combination of micro columns packed with smaller particles and optimized detectors.

The ability to isolate and identify differences between commercial beverage samples is made possible using non-targeted Pegasus® GC-TOFMS and ChromaTOF software’s Reference compare tool. This novel approach is an ideal strategy for quality control purposes and building brand awareness.

This application note presents a rapid and inexpensive method for BPA screening in milk samples using a monolithic Chromolith® HighResolution RP-18 endcapped column and fluorescence detection on a Chromaster HPLC system.