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Fields & Applications Liquid Chromatography, Mass Spectrometry, Data Analysis, Proteomics

Bridging the Biomarker Gap

Biomarker discovery and validation relies heavily on reproducible and robust analytical methodology. Separation science and notably high performance liquid chromatography (HPLC) are essential and efforts spent in developing more efficient and robust HPLC stationary phases, together with advanced mass spectrometers, have made modern biomarker research possible. Given that many clinical biomarkers are proteins, advances in protein bioanalysis and proteomics have also been critical in driving the biomarker field forward. Many new biomarker candidates are proposed for various diseases every week – but often from small-scale studies lacking statistical power.

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About the Author

Rainer Bischoff

In 1987, Rainer Bischoff joined Transgene (Strasbourg, France) where he began protein-related research. He pioneered the application of mass spectrometry to characterizing recombinant proteins and published one of the first papers on this technique in 1990. Rainer continued his industrial career at AstraZeneca R&D (Lund, Sweden) before joining the Faculty of Mathematics and Natural Sciences at the University of Groningen (The Netherlands) in 2001, where he is full professor of Analytical Biochemistry. His research interests focus on biomarker discovery and validation, bioinformatics, the bioanalysis of biopharmaceutical proteins and the development of novel instrumental analytical techniques. He is the author of more than 160 peer-reviewed publications and book chapters and holds 12 patents.

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