Landmark Literature 2018: Part II
Every year, we ask experts from across the analytical sciences to select one eye-catching article from the past 12 month. Here, the rising stars from our Top 40 Under 40 Power List pick their top papers of 2018 – and tell us why.
Sergio C. Nanita, Mikhail Savitski, Ken Broeckhoven, Jean-Francois Masson, Anneli Kruve, Juris Meija, Cecilia Cagliero, Hiroshi Tsugawa | | Longer Read
De-Bugging Mass Spec Data
By Hiroshi Tsugawa, Researcher, RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.
Landmark paper: H Mohimani et al., “Dereplication of microbial metabolites through database search of mass spectra”, Nat Comm, 9, 4035 (2018).
Advances in computational mass spectrometry are essential to grasp the diversity of metabolomes in living organisms. Metabolite annotation is straightforward when an authentic standard compound is available; however, the coverage (<5 percent) of mass spectral libraries is far removed from the structural diversity found in biological samples. To increase the coverage of metabolic profiling in biology, we need a standard-free annotation pipeline.
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