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Fields & Applications Proteomics, Pharma & Biopharma, Metabolomics & Lipidomics, Mass Spectrometry, Liquid Chromatography, Data Analysis, Sensors, Environmental, Clinical, Genomics & DNA Analysis

Landmark Literature 2018: Part II

De-Bugging Mass Spec Data

By Hiroshi Tsugawa, Researcher, RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.

Landmark paper: H Mohimani et al., “Dereplication of microbial metabolites through database search of mass spectra”, Nat Comm, 9, 4035 (2018).

Advances in computational mass spectrometry are essential to grasp the diversity of metabolomes in living organisms. Metabolite annotation is straightforward when an authentic standard compound is available; however, the coverage (<5 percent) of mass spectral libraries is far removed from the structural diversity found in biological samples. To increase the coverage of metabolic profiling in biology, we need a standard-free annotation pipeline.

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Landmark Literature 2018

Fields & Applications Proteomics

Landmark Literature 2018: Part I

| Michael Witting, M Farooq Wahab, Anna Laura Capriotti, James Grinias, Matthew Baker, Caroline West, Andrea Gargano, Francesco Cacciola

The rising stars from our Top 40 Under 40 Power List pick their top papers of 2018.

About the Authors

Sergio C. Nanita

Sergio C. Nanita is a Principal Investigator at DuPont Industrial Biosciences, Wilmington, Delaware, USA.


Mikhail Savitski

Mikhail Savitski is Team Leader and Head of Proteomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.


Ken Broeckhoven

Ken Broeckhoven is Associate Professor at the Department of Chemical Engineering, Vrije Universiteit Brussel, Brussels, Belgium.


Jean-Francois Masson

Jean-Francois Masson is Professor of Chemistry, Université de Montréal, Canada.


Anneli Kruve

Anneli Kruve is Humboldt Fellow, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Germany.


Juris Meija

Research Officer, Metrology, National Research Council Canada, Ottawa, Canada.


Cecilia Cagliero

Cecilia Cagliero is Assistant Professor, Department of Drug Science and Technology, University of Turin, Italy.


Hiroshi Tsugawa

Hiroshi Tsugawa is a Researcher at RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.

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