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Fields & Applications Proteomics, Genomics & DNA Analysis, Mass Spectrometry, Metabolomics & Lipidomics, Clinical

Toward Integrative Omics

I started researching colorectal cancer for multiple reasons, but a significant part of my interest was triggered by grief; a member of my immediate family died as a result of metastatic colorectal cancer, despite having the access to the best medical care. I wanted to understand more of what had happened and why.

Reading about colorectal cancer, it was apparent that while the genomics and transcriptomics of the disease had been well studied, the proteomic changes that accompany the disease were not as well understood. I believe the prejudice is related to the tools that were/are available to tackle the problem. After realizing how much remained to be done in the field of cancer proteomics, I decided to devote my career to studying the molecular changes that underwrite colorectal cancer. The more I work in this field, the more I recognize how truly deep understanding – from genotype to phenotype – is the only way we can tackle cancer.

Omics in the Literature

What does analysis of the last 15 years of literature on the different omics tell us about the growing importance of the field, and the move towards a more integrated approach?

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About the Author

Amanda Hummon

Amanda Hummon is Huisking Foundation Inc. Associate Professor at University of Notre Dame, Indianapolis, USA. The interests of the Hummon Research Group lie at the intersection of analytical chemistry and chemical biology, with a focus on cancer biology. They develop high-throughput methods to evaluate the proteome and transcriptome in cancer cells.

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