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February 2016 Issue of The Analytical Scientist

Welcome to February’s issue! From sports doping to legal highs, it’s (almost) all about the drugs, with experts from both fields looking at what analytical scientists can do as consumption rises. Four spectroscopy gurus discuss the finer points of surface enhancement in the light of a disruptive new model, while we offer our Pittcon picks and editor Rich asks if genetic modification of embryos heralds a dystopian future. Lutgarde Buydens talks chemometrics, collaboration and defying the data tsunami. And just as the judges are deliberating over the winner for 2016, we speak with the exceptional runners up from the 2015 Humanity in Science Award.

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Articles featured in this issue

Fields & Applications Genomics & DNA Analysis

G-A-T-T-A-C-A

| Rich Whitworth

Imagine a society where people are discriminated against due to genetic predisposition to disease…

Techniques & Tools Forensics

The Gloves Are Off

| Joanna Cummings

What can experts in analytical sciences do - if anything - to stop sports doping?

Techniques & Tools Spectroscopy

Georgia (and Pittcon) On My Mind

| Joanna Cummings

Get the most out of Pittcon, Atlanta with our top picks from the sessions.

Fields & Applications Materials

Bringing MOFs Down to Size

| James Strachan

MOFs can now be nano-fabricated - what impact could the materials have on analytical science?

Techniques & Tools Forensics

Plug-and-Play Forensic MS

| Christopher Mulligan

Portable mass spectrometry readies itself for on-site identification of physical evidence.

Fields & Applications Food, Beverage & Agriculture

Fish Pharm

| Joanna Cummings

Drugs get a second chance to enter our bodies - via wastewater and fish…

Fields & Applications Forensics

Image of the Month

| Rich Whitworth

CSI versus PSI: Forensic evidence can be applied to a paper triangle

Techniques & Tools Pharma & Biopharma

The Search for the Ideal Detector

| Dorina Kotoni

Will aerosol-based detectors ever meet all the needs of the pharmaceutical industry?

Techniques & Tools Liquid Chromatography

Is Your Biomarker Analysis Accurate?

| James Settlage

Time to take the plunge with supercritical fluid chromatography in bioanalytical applications

Techniques & Tools Capillary Electrophoresis

Microchip-CE: Smaller is Faster

| Friederike Winkhaus

Exploring the potential of microchip capillary electrophoresis to speed up sample throughput

Techniques & Tools Metabolomics & Lipidomics

Waste Not, Want Not

| Julien Wist, Elaine Holmes

Isn't it time to share resources to open up more opportunities for metabolic profiling?

Techniques & Tools Spectroscopy

Gurus of Raman Spectroscopy

| Volker Deckert, Duncan Graham

In the light of a disruptive new paper, four experts discuss the future of Raman spectroscopy

Techniques & Tools Pharma & Biopharma

Legal Highs & Lows

| Amira Guirguis

Amira Guirguis offers an overview of new psychoactive substances (NPS) and designer drugs.

Fields & Applications Liquid Chromatography

The Analytical War on Novel Psychoactive Substances

|

Why anybody would eat plant food let alone abuse its use is bemusing.

Techniques & Tools Mass Spectrometry

Solving Problems for the Greater Good

| Joanna Cummings

One year on, we speak with the exceptional runners up from the Humanity in Science Award 2015.

Techniques & Tools Data Analysis

Defying the Data Tsunami

| Lutgarde Buydens

We talk to Lutgarde Buydens, Professor Analytical Chemistry: Chemometrics, Radboud University

Fields & Applications Technology

Solving the challenges of Leachable pharmaceutical impurities using a full analytical portfolio

| Stephen Guilfoyle

Extractables and leachable compounds are a complex and ever growing list of pharmaceutical impurities

Techniques & Tools Pharma & Biopharma

Talking Extractables & Leachables with Smithers Rapra

| Andrew Feilden

Hear how new developments in analytical technology are providing additional insights into unknown contaminants

Fields & Applications Technology

Talking Extractables & Leachables with Glaxo Smith Kline

| Jason Creasey

Hear from industry expert Jason Creasey as he discusses the history of extractable and leachable testing

Techniques & Tools Mass Spectrometry

Development and utilization of cloud based libraries for unknown contaminant identification

Hear from Dr. Robert Mistrik (HighChem) as he presents on the latest free-to search online high resolution accurate mass spectral library

Techniques & Tools Sample Preparation

Case study of a semi-pure β-amylase extract

| Sponsored by Malvern Panalytical

The investigative power of multiple detectors. Here, we describe the analysis of a semi-purified protein mixture containing β-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how coupling this data can be qualitatively and quantitatively evaluated.

Techniques & Tools Sample Preparation

Characterizing polysaccharide structure with SEC-MALS and intrinsic viscosity measurements

| Sponsored by Malvern Panalytical

In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied.

Other issues of 2016