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April 2013 Issue of The Analytical Scientist

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Articles featured in this issue

Fields & Applications

Is Industrial Research the New Gold Standard?

| Richard Gallagher

Considered for so long to be the poor relation to academia, industry researchers may well represent the best of science.

Techniques & Tools Technology

Digital Versatile DNA

| Rich Whitworth

Can deoxyribonucleic acid solve our spiralling digital data archive conundrum? Hard disc drive space is now ... measured in terabytes not megabytes. And yet still we run out of space – or money.

Techniques & Tools Preparative/Process Chromatography

Modular Protein Purification

| Rich Whitworth

Thoughtful yet simple product development proves that faster, higher, better aren’t the only keywords for ... innovation.

Techniques & Tools Mass Spectrometry

Every Dog Has Its Day

| Rich Whitworth

A new “sniff” test for explosives uses direct, real-time vapor detection in a bid to put our canine colleagues ... out of work in the screening of people, baggage and cargo.

Techniques & Tools Micro/Nano-scale

Meeting Expectations

| Rich Whitworth

This year’s Symposium on MicroScale Bioseparations introduced a new format aimed at optimizing the ... scientific experience. How did it go?

Techniques & Tools Mass Spectrometry

Family Affair

| Rich Whitworth

Günther Laukien, founder of Bruker Physik AG, posthumously receives 2013 Pittcon Heritage Award ...

Fields & Applications Chemical

Talking of Heritage...

| Rich Whitworth

Recording the impact of chemistry on society, the Chemical Heritage Foundation's participation in Pittcon adds valuable, historical depth.

Techniques & Tools Data Analysis

Yes, We Have a Quality Manager

| Peter Kootstra

Why lab SOPs are cumbersome and often ignored, and what can be done to improve them ...

Techniques & Tools Mass Spectrometry

Instrumental to Success

| Steve Cohen

An illustration of how working with customers throughout development increases the effectiveness of ... new products.

Fields & Applications Micro/Nano-scale

Excitement on the Smallest Scale

| Steve Carrington

Microrheology is in its early stages, but it has the potential to expand the range and enhance the application of rheological characterization.

Fields & Applications Pharma & Biopharma

The S-Word and US Research

| Bill Kelly

What short- and long-term impact will sequestration have on the US scientific community?

Fields & Applications

Quality Improvement Provides New Choices and Greater Capability

| Allen K. Vickers

Scientific innovation combined with manufacturing excellence continues to drive improvements in GC.

Fields & Applications Mass Spectrometry

Spot On

| Sangeeta Tanna, Graham Lawson

Dried Blood Spot (DBS) sampling is being adopted in drug development, paediatric healthcare, and, more recently, patient compliance.

Fields & Applications Mass Spectrometry

Dried Blood Spot 101

| Sangeeta Tanna, Graham Lawson

Introduced by Robert Guthrie in the 1960s, dried blood spot (DBS) sampling involves taking small drops ... of blood from either a finger prick (or heel prick in neonates) and depositing them on specially manufactured absorbent card where they are allowed to dry. Once dry, DBS cards can be readily transported by post for analysis since the components of the blood remain unchanged for several days, even at room temperature. For analysis, a portion of the blood spot is removed from the card and placed in a solvent to extract the analyte(s) of interest.

Fields & Applications Genomics & DNA Analysis

Principal Drivers for DBS Research

| Sangeeta Tanna, Graham Lawson

It is now recognised that regarding a child as a scaled down adult to calculate a medicine dose may not be appropriate.

Fields & Applications Sample Preparation

Confronting Concerns

| Sangeeta Tanna, Graham Lawson

With many potential benefits, it is easy to understand the drive to develop systems and methods acceptable to the regulatory authorities.

Techniques & Tools Technology

The Tools of Proteomics

| Norm Dovichi, Amanda Hummon

The proteome, which is the set of proteins expressed by a genome, cell, tissue or organism at a given time ... presents immense analytical challenges – but offers substantial rewards. Here, current approaches to proteomics, their strengths and their shortcomings, are explored.

Techniques & Tools Mass Spectrometry

Antimicrobial Abuse

| Richard Stadler

In response to the over-dependence and misuse of antimicrobials in food producing animals, ... analytical testing and surveillance is being stepped up. Here, current best practice and likely directions for monitoring antimicrobials is described.

Fields & Applications Food, Beverage & Agriculture

Antimicrobial Trends and Risks

The use of antimicrobials as growth promoters in livestock has sparked serious concern about the development of drug-resistant strains of pathogens.

Techniques & Tools Technology

Patent Pitfalls

| Hilary van der Hoff, Simon Kiddle

There is little advice available on the pitfalls that await the unwary scientist filing a first patent ... application ... or general advice to those put in charge of managing the intellectual property for his or her start up. Here, we identify some of the most common mistakes made when patent applications are prepared and filed – and how to avoid them.

Fields & Applications Liquid Chromatography

Publish, or Perish the Thought?

| Lloyd Snyder

Research papers are the bread and butter of an academic’s career, but a different mindset prevails in industry. Should it?

Fields & Applications Chemical

Casting Monoliths in a Molecular Foundry

| Richard Gallagher

Sitting Down With Frantisek Svec, Facility Director, Organic and Macromolecular Synthesis Facility, Lawrence Berkeley National Laboratory.

Fields & Applications Spectroscopy

GPC/SEC-MALLS analysis of Hyaluronic Acid

| Sponsored by PSS

Hyaluronic acid is a polymer of disaccharides and can have up to 25,000 disaccharide repeat units.

Other issues of 2013