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June 2016 Issue of The Analytical Scientist

Welcome to the June issue! In Upfront, we share a new approach for imaging the lungs of newborns, innovations in mass spec, and find out how The Hunger Games and PTR-MS helped track the chemistry of group emotion. From peptide chemistry to technology development to the analysis of colorectal cancer, our experts demonstrate the power, potential and inevitability of multi-omic efforts. Finally, we Sit Down With Jessica Prenni, talk food fraud with Petter Olsen and find out what Jenny Van Eyck has learned throughout her varied career.

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Articles featured in this issue

Techniques & Tools Microscopy

Open Access Fraud

| Rich Whitworth

The world is in serious trouble when “Photoshop” is added as a major skill on the curricula vitae of scientists.

Fields & Applications Mass Spectrometry

Baited Breath

| Joanna Cummings

Using PTR-MS to track the chemistry of group emotion

Techniques & Tools Mass Spectrometry

Small and Mighty

| Joanna Cummings

Is a new and improved mass spectrometer the “Holy Grail” of chemical sensing?

Techniques & Tools Spectroscopy

Holding Back the Years

| Joanna Cummings

Using Raman spectroscopy to track hyaluronic acid permeation in skin

Techniques & Tools Technology

Looking for a Lab?

| Rich Whitworth

Finding a research partner just got a lot easier

Fields & Applications Spectroscopy

The Lungs of Babes

| Joanna Cummings

Near-infrared spectroscopy may allow non-invasive monitoring of premature babies

Business & Education Mass Spectrometry

Launches, Libraries and Lipid Analyses

| Rich Whitworth, Marcus Lippold

What’s new in business this month?

Fields & Applications Spectroscopy

Image of the Month

| Joanna Cummings

Researchers at the Dresden University of Technology can now determine the sex of a chicken before it hatches – in under a minute.

Techniques & Tools Gas Chromatography

RIP GC?

| Ray Perkins

When disruptive technology comes along, it can be hard to defend the technique under attack for some applications – even if we have embraced it for decades.

Techniques & Tools Pharma & Biopharma

The Dose Makes the Poison!

| David Elder

Detecting and controlling mutagenic impurities in pharmaceuticals is challenging. What is ICH M7 and what do you need in your analytical toolbox?

Techniques & Tools Pharma & Biopharma

Long Live the Microsample

| Neil Spooner

When it comes to microsampling for quantitative bioanalysis, the devil is certainly in the details. But we should learn from our mistakes – not retreat back into convention.

Techniques & Tools Liquid Chromatography

Neglected Micro LC

| Thorsten Teutenberg

Is now the right time for HPLC’s diminutive cousin to make a comeback in routine analysis?

Fields & Applications Proteomics

Toward Integrative Omics

| Amanda Hummon

Cancer is incredibly complex, posing enormous challenges beyond the biological field. Taking a multi-omic approach can help us make sense of this diverse set of diseases – and, ultimately, allow us to better understand ourselves as human beings.

Fields & Applications Mass Spectrometry

The ‘One Pot’ Approach

| Tom Metz

Tom Metz, Integrative Omics Scientist and Metabolomics Technical Lead at Pacific Northwest National Laboratory (Washington State, USA), selects six papers that exemplify the power of multi-omics.

Techniques & Tools Proteomics

Lessons I’ve Learned, with Jenny Van Eyk

| Jennifer Van Eyk

From hardcore peptide biochemist to translational scientist, it’s been an unconventional journey for Jennifer Van Eyk, Director of the Advanced Clinical Biosystems Research Institute at Cedars-Sinai Medical Center, Los Angeles. Here, Jenny tells us what she’s learnt along the way.

Fields & Applications Food, Beverage & Agriculture

Casting A Wider Net

| Petter Olsen

When fighting food fraud, there are problems that analytical science alone cannot solve. We must work together to take a more inclusive and multidisciplinary approach that ensures true food integrity.

Techniques & Tools Technology

Icebergs Ahead

| Tony Lisi

Are you ready for the “unthinkable” – your laboratory computer systems suffering a titanic failure? Disaster recovery plans are crucial insurance against the unexpected.

Fields & Applications Mass Spectrometry

Core Collaborator

| Jessica Prenni

Sitting Down With... Jessica Prenni, Director of Research Core Facilities, Director of Proteomics & Metabolomics Facility, Colorado State University, USA.

Techniques & Tools Mass Spectrometry

High Hopes for High Resolution

| Rich Whitworth

Then & Now, with Amadeo Fernández-Alba, Professor at the University of Almeria, Spain.

Techniques & Tools Sample Preparation

Protein Applications for Advanced Multi-Detector Size-Exclusion Chromatography

| Sponsored by Malvern Panalytical

In this application note, a mixture of four proteins was characterized in a single SEC measurement using multiple detectors. The generally consistent response to the RI to proteins makes it a useful total protein concentration detector, while the UV detector can be used to measure the concentration of individual proteins when the extinction coefficient is known. This is particularly useful for proteins that elute in the solvent peak making RI measurements unreliable. Finally, light scattering measurements allow each peak to be identified by its molecular weight.

Fields & Applications Sample Preparation

Identification of foreign particulate matter using the Morphologi G3-ID

The Morphologi G3-ID enables simultaneous physical and chemical characterization of particle samples, enabling outlier particles to be identified as being part of a product formulation or genuine foreign particle contaminants.

Other issues of 2016