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November 2015 Issue of The Analytical Scientist

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Articles featured in this issue

Techniques & Tools Gas Chromatography

The Power of Passionate Debate

| Rich Whitworth

Peer reviews, Power Lists and the effects of heat (in GC and discussions).

Techniques & Tools Data Analysis

LC-MS Versus GC-MS

| Rich Whitworth

Is the heat applied in gas chromatography-mass spectrometry really responsible for false results? And, if so, how often?

Techniques & Tools Spectroscopy

TXRF Goes Nuclear

Using total reflection X-ray fluorescence for the non-destructive analysis of nuclear fuel oxides

Techniques & Tools Food, Beverage & Agriculture

Hot (Dog) or Hype?

| Rich Whitworth

Kickstarter technology is nothing new – but Clear Labs is making in-roads into something less common: kickstarter analytical science

Fields & Applications Genomics & DNA Analysis

Gold Rush

| Rich Whitworth

Nanoporous gold helps ‘sieve out’ biological debris for fuss-free nucleic acid detection

Fields & Applications Genomics & DNA Analysis

Name Your Poison

| Roisin McGuigan

A new DNA-based sensor shows promise for indirect detection of thallium

Techniques & Tools Capillary Electrophoresis

Is CE-MS in Your Toolbox?

| Rob Haselberg

Online hyphenation of capillary electrophoresis and mass spectrometry is nearly 30 years old, but has been ignored in certain camps. It’s time to give CE-MS a chance.

Techniques & Tools Mass Spectrometry

The Six Dimensions of GC

| Nicholas Snow

The juxtaposition of simplicity through new technology with complexity in the chemistry keeps gas chromatographic method development exciting – despite GC being described by many as a “mature” technique. But are we still using packed-column thinking?

Techniques & Tools Data Analysis

Data: Wanted Dead or Alive

| Ryan Sasaki

Can R&D organizations really afford to kill off analytical data that could be used for future decision-making? Perhaps it’s time to breathe life back into analytical data environments.

Techniques & Tools Data Analysis

The Drug Concentration Conundrum

| Marcel Florin Musteata

When it comes to measuring drugs in biological samples, what is needed, what is quantifiable – and what role should analytical scientists really be playing?

Techniques & Tools Gas Chromatography

Landmark Literature: 2015 (part1)

| Davy Guillarme, Hans-Gerd Janssen

We ask an impossible question as 2015 comes to a close: which piece of literature stood out from the crowd

Techniques & Tools Spectroscopy

Landmark Literature: 2015 (part2)

| Martin Gilar , Peter Griffiths

Just imagine how many analytical problems would be solved if we could increase the resolution of liquid chromatography (LC) from hundreds to thousands or perhaps a hundred thousand compounds?

Techniques & Tools Liquid Chromatography

Landmark Literature: 2015 (part3)

| Pat Sandra, Peter Schoenmakers

Selecting “the paper of the year” is by definition subjective and very personal.

Techniques & Tools Mass Spectrometry

Gurus of CE-MS

| Michael Knierman, Norman (Norm) Dovichi, Rob Haselberg, Tomoyoshi Soga, Christian Wenz

Capillary electrophoresis-mass spectrometry (CE-MS) appears to be caught in a dichotomy – proven success in some fields, skepticism in others.

Techniques & Tools Mass Spectrometry

Finding a Piece of the Protein Characterization Puzzle

| Tiemin Huang

Coupling whole column imaging detection to a mass spectrometer for protein structure characterization is fundamentally challenging. Could a relatively simple capillary cartridge system unlock the potential?

Fields & Applications Mass Spectrometry

Swiss Precision Research

| Rich Whitworth

Sitting Down With… Detlef Günther, VP Research and Corporate Relations, and Professor for Trace Element and Micro Analysis, ETH Zürich, Switzerland.

Techniques & Tools Mass Spectrometry

The Simple Beauty of TLC-MALDI-MS

| Rich Whitworth

Thin-layer chromatography’s ability to simply and inexpensively provide high-quality separations in parallel makes it the perfect partner for MALDI mass spectrometry

Fields & Applications Mass Spectrometry

The Never-Ending Challenge of Pesticide Analysis

| Rich Whitworth

A growing target list, increasingly complex matrices, and the need for low limits of detection can make our field seem like an uphill treadmill.

Fields & Applications Spectroscopy

Bringing New Life to Old Arteries with Oxygen

| Cicely Rathmell

Optimizing oxygen delivery improves stem cell treatment of peripheral artery disease.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 1

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part One, we provide an overview of the key principles of DLS: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 2

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Two, we cover the influence of concentration effects and particle interactions on DLS results and provide a roadmap for identifying and distinguishing each type of concentration effect.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 3

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Three, we cover the basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.

Fields & Applications Sample Preparation

Overview of Key Principles of Dynamic Light Scattering to protein therapeutic formulations – Part 4

This four-part series examines common issues and questions surrounding the principles, measurements and analysis of DLS data and discusses how to minimize the time required for and increase the accuracy of acquiring and interpreting DLS data during the biotherapeutic development process. In Part Four, we address frequently asked questions related to the application of DLS to the characterization of protein therapeutic formulations.

Fields & Applications Spectroscopy

How to Maximize Absolute Molecular Weight Measurement Accuracy: Synthetic Polymers

The molecular weight, molecular weight distribution and size of three common polymers are measured using OMNISEC. This information can provide insight into the physical properties and behavior of these synthetic polymers.

Fields & Applications Sample Preparation

The application of MicroCal VP Capillary DSC at a contract development organization

See how you can use DSC to save you money in your contract development lab. This paper provides an overview of the workflow typically associated with preformulation projects at a contract development organization as well as provides a general framework for conducting preformulation studies that leverages the application of biophysical techniques such as DSC and traditional analytics by employing statistical design. A case study involving the formulation development of a monoclonal antibody is presented to detail the utility and potential limitations of DSC in support of preformulation for a variety of protein products.

Fields & Applications Technology

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies Choosing the best antibody to progress in your biologic pipeline. Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments. Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline.

Other issues of 2015