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December 2015 Issue of The Analytical Scientist

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Articles featured in this issue

Fields & Applications Mass Spectrometry

We’ve Only Just Begun...

| Rich Whitworth

Three years on, and our mission to record, celebrate and scrutinize analytical science is as strong as ever.

Techniques & Tools Technology

Laptop Lab

| Peter Willis

Could NASA’s “chemical laptop” breathe new life into the search for extraterrestrials?

Techniques & Tools Mass Spectrometry

Keeping Up with the Dopers

| James Strachan

A new LC-MS/MS screening method simultaneously detects a wide range of non-banned potentially performance enhancing drugs and masking agents in urine

Fields & Applications Forensics

The Forensic Acid Test

| James Strachan

Criminals “sweating it out” beware: a new amino acid test can tell male from female fingerprints

Techniques & Tools Mass Spectrometry

Exporting Analytics

| James Strachan

GSK and the RSC embark on a five-year partnership to bring GC-MS skills to Africa

Techniques & Tools Gas Chromatography

Spot the Rot

| James Strachan

Could carbon nanotubes hold the key to real-time, portable testing for meat freshness?

Techniques & Tools Gas Chromatography

Celebrating Innovation – and 25 Years of SPME and GC×GC

| Abhijit Ghosh

Two important innovations in analytical science have reached their 25th anniversaries: solid phase micro-extraction (SPME) and comprehensive two-dimensional gas chromatography (GC×GC). Here’s why I think they are worth applauding.

Techniques & Tools Spectroscopy

Teaching Computers Plasma Physics

| Vincenzo Palleschi

The analytical performance of laser-induced breakdown spectroscopy (LIBS) can be improved dramatically by using an artificial neural network approach, opening up new opportunities for its application.

Techniques & Tools Liquid Chromatography

When No Standard is the Gold Standard

| Thomas Jocks

Can multi-angle light scattering aid in the characterization of proteins and antibody drug conjugates?

Techniques & Tools Liquid Chromatography

What is pH?

| William Tindall

This short and seemingly simple question belies the complexity of measuring – and interpreting – pH.

Techniques & Tools Mass Spectrometry

The Pros and Cons of Direct Injection

| Torsten Schmidt

In water analysis, direct injection of samples into your LC-MS/MS system (without sample preparation beyond filtration) is possible because of advances in instrumentation. However, matrix effects must be monitored carefully – and sometimes may even prove useful.

Techniques & Tools Technology

Return of the TASIAs

| Rich Whitworth

The Analytical Scientist Innovation Awards (TASIAs) return for a third consecutive year to recognize 12 months of innovation from companies big and small.

Techniques & Tools Mass Spectrometry

Exploring Chirality in Outer Space

| Volker Schurig

What is the origin of stereochemical bias – terrestrial autocatalytic processes, extraterrestrial contamination or otherworldly intervention? Here, I review the gas chromatographic tools being used in the search for homochirality in space – the final frontier.

Techniques & Tools

Manuscript Master Class

| Steven Lehotay

Getting your work published in a high-quality, peer-reviewed journal isn’t easy. But if you follow these 40 tips, you could at least avoid common errors that frustrate reviewers.

Techniques & Tools Pharma & Biopharma

Going Further Together

| Deirdre Cabooter

Sitting Down With… Deirdre Cabooter, Assistant Professor, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium, and HTC-14 committee member.

Techniques & Tools

Product Showcase

Two companies present their contributions to the analytical science community.

Fields & Applications Mass Spectrometry

To Attograms and Beyond

| Donald G. Patterson Jr.

Every year sees new chemicals added to the list of analytes that may need to be measured in a given sample. At the same time, environmental levels of many older pollutants may be in decline – but still must be measured.

Fields & Applications Mass Spectrometry

Protecting Our Most Precious Resource: Water

| Heinz Singer

New analytical capability can have a significant impact on research direction.

Fields & Applications Mass Spectrometry

Raising the Bar for Routine Analysis

| Sponsored by Thermo Fisher Scientific

The Pesticide Explorer Collection comprises four complete workflows that meet the challenges of modern pesticide residue analysis.

Techniques & Tools Liquid Chromatography

Exploring the Economics of Innovation

| Sponsored by Agilent Technologies

Continual advances in liquid chromatography have raised the bar from high performance to ultra-high performance, resulting in increased analytical, instrument, and laboratory efficiency. What’s holding you back from investments in UHPLC technology?

Fields & Applications Technology

Application of microcalorimetry in drug discovery at Exelixis

In this report, we illustrate the utility of calorimetry in making better laboratory decisions. Examples will include improved protein construct selection for scale-up; direct measurement of the effects of mutations and post-translational modifications on protein stability; rapid optimization of solvent formulation; direct measurement of substrate and inhibitor binding affinity; determination of the mode of inhibitor binding; characterization of protein-protein interactions; and improved structural biology efficiency, when used in conjunction of other biophysical methods.

Fields & Applications Sample Preparation

Polyol-induced increases in thermal stability of antibodies by DSC

Polyol-induced increases in thermal stability of antibodies. See how Differential scanning calorimetry can be used to assess the effects of polyol excipients on antibodies. DSC was used to monitor polyol-induced increases in thermal stability across seven monoclonal antibodies. The increases in thermal stability were measured as a function of polyol concentration and orientation of hydroxyl groups. It was found that increases in thermal stability were linear with respect to alcohol concentration.

Fields & Applications Sample Preparation

Evaluating the rheological properties of hyaluronic acid hydrogels for dermal filler applications

To formulate successfully with HA it is essential to understand the impact of factors such as molecular weight, molecular structure, concentration and degree of cross-linking on rheological characteristics such as viscoelasticity which are directly linked to aspects of product performance. Linking structural characteristics to product performance, via rheological properties, supports smart, fast, and effective formulation. The following study shows how rheology and particle size measurements can be used to characterize the physical properties of HA dermal fillers.

Other issues of 2015