Objective:

To explore the concept of using molecular glues to restore protein-protein interactions that are absent or malformed, potentially aiding in disease treatment.

Approach:

• Research Collaboration: Joint research by the Universities of Leicester and Birmingham focused on the application of molecular glues in protein interactions.
• Mass Spectrometry Technique: Utilized modern native mass spectrometry to separate proteins, protein-protein complexes, and identify potential glues.
• Performance Monitoring: Monitored the effects of adding mixtures of potential glues to proteins to determine the best candidates for restoring interactions.

Key Findings:

• Molecular glues can potentially bind proteins together to restore proper interactions.
• Mass spectrometry can effectively identify and screen for potential molecular glues.

Interpretation:

Limitations:

• Research was halted during lockdown, limiting experimental progress.
• Further validation and testing are required to confirm the efficacy of identified glues.

Conclusion:

Sources:

• The Medicine Maker