The biopharma sector is undergoing rapid evolution, with new technologies and methodologies shaping the way we tackle analytical challenges in drug development and manufacturing. In this eBook, we present a curated selection of insightful articles that capture the exciting developments in this field.
Brandon Ruotolo from the University of Michigan discusses how ion mobility-mass spectrometry (IM-MS) is enhancing the characterization of monoclonal antibodies (mAbs), providing rapid, in-depth insights into mAb aggregation – a process that significantly impacts biotherapeutic safety and efficacy. Ruotolo explains, “mAb aggregation is a complex, poorly understood phenomenon that we hope to clarify with the advanced resolution offered by IM-MS.” His team’s work highlights the potential of this technique to streamline bioprocessing and improve patient outcomes.
Andrei Fedorov from Georgia Tech introduces the Dynamic Sampling Platform (DSP), a novel approach to real-time, automated monitoring in cell therapy manufacturing. With DSP, Fedorov’s team was able to detect critical biomarkers rapidly, bringing automation and precision to an area in dire need of innovation. “The ultimate goal is fully automated, multi-omic monitoring in biomanufacturing,” Fedorov notes, envisioning a future where continuous quality control is the standard in advanced therapy production.
We also feature a compelling article by Eliza Lee, Lead Scientist at Samsung Biologics, where she delves into the cutting-edge techniques used for biotherapeutic molecule characterization. From enzyme-linked immunosorbent assays (ELISA) to glycan analysis, Lee highlights the importance of advanced analytical methods in bringing biotherapeutics to market faster and with greater accuracy.
Additionally, don’t miss our in-depth interview with Koen Sandra, CEO of RIC Group and Visiting Professor at Ghent University, Belgium. Sandra shares insights on the evolution of biopharma analysis, the growing importance of life sciences, and how his family’s legacy has shaped his career. He offers a unique perspective on the future of biopharma, including the impact of automation, artificial intelligence, and the ongoing shift towards cell and gene therapies.
From cutting-edge mass spectrometry techniques to the future of cell therapy automation, this eBook offers an insightful look into the technological breakthroughs that are driving the biopharma industry forward. Download it now to stay ahead of the curve in this dynamic field.
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