Objective:

To optimize solid-phase extraction methods for the detection of PFAS and ultra-short chain PFAS using LC-MS/MS.

Key Findings:

• Solid-phase extraction methods were successfully optimized for PFAS detection.
• The use of an activated carbon-packed delay column significantly enhanced detection efficiency.

Interpretation:

The findings suggest that optimized solid-phase extraction combined with advanced column technology can lead to more accurate and sensitive detection of PFAS compounds.

Limitations:

• The study may not cover all types of PFAS compounds.
• Further validation in diverse environmental samples is needed.

Conclusion:

Optimizing solid-phase extraction techniques is crucial for improving the detection of PFAS and ultra-short chain PFAS in various samples.