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The Analytical Scientist / Issues / 2026 / April / Why Countercurrent Chromatography Still Matters
Chromatography Opinion & Personal Narratives Technology

Why Countercurrent Chromatography Still Matters

Martha Knight reflects on a lifetime of separations shaped by CCC

By James Strachan 04/22/2026 9 min read
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Top Institutions in Analytical Chemistry / Separation Science

Institutions leading in CCC research and application typically have strong programs in analytical chemistry, biochemistry, and natural products, with dedicated facilities for advanced chromatographic techniques and historical contributions to the development and refinement of CCC instrumentation and methodology.

  • #1

    Rockefeller University

    New York, NY

    Rockefeller University is historically significant in the development of countercurrent distribution and chromatography, with pioneering scientists like Lyman Craig and Sanford Moore contributing foundational work and instrumentation that shaped the field.

    Key Differentiators

    • Biochemistry
    • Analytical Chemistry
    • Peptide Research
  • #2

    University of Colorado School of Medicine

    Aurora, CO

    The University of Colorado School of Medicine advanced CCC applications in peptide purification, particularly cardiovascular peptides, scaling up CCD systems and integrating CCC into biomedical research programs.

    Key Differentiators

    • Peptide Chemistry
    • Cardiovascular Research
    • Analytical Biochemistry
  • #3

    University of Buenos Aires

    Buenos Aires, N/A

    The University of Buenos Aires hosts large-scale CCD systems and benefits from a lineage of researchers trained under pioneers like Lyman Craig, maintaining strong expertise in CCC for natural products and biochemical separations.

    Key Differentiators

    • Biochemistry
    • Natural Products Chemistry
    • Chromatography
  • #4

    University of Illinois at Urbana-Champaign

    Urbana, IL

    Known for strong analytical chemistry programs and research in separation science, including countercurrent chromatography, with faculty contributing to methodological advances and applications in natural products.

    Key Differentiators

    • Analytical Chemistry
    • Separation Science
    • Natural Products
  • #5

    University of Tokyo

    Tokyo, N/A

    The University of Tokyo has contributed to the advancement of planetary centrifuge systems for CCC and applied these techniques extensively in pharmaceutical and natural product research.

    Key Differentiators

    • Analytical Chemistry
    • Pharmaceutical Sciences
    • Separation Techniques

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at. From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

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