5 Key Takeaways

• 1

  The study investigates how metal homeostasis disturbances affect metabolism in Caenorhabditis elegans.

• 2

  Zinc is identified as a central regulator of metal balance, influencing the distribution of iron and manganese.

• 3

  Chronic iron exposure leads to significant shifts in metabolites linked to central carbon metabolism.

• 4

  Neurons may be particularly vulnerable to metabolic strain from disrupted metal homeostasis.

• 5

  The research advocates for combining metal speciation analysis with metabolomics to explore metal dysregulation effects.