5 Key Takeaways

• 1

  Targeted nano-DESI tandem mass spectrometry imaging effectively separates low-abundance plasmalogens from more abundant lipids in mouse brain tissue.

• 2

  A workflow developed by Julia Laskin's group resolved 38 plasmalogen species and revealed distinct distributions across various brain regions.

• 3

  A new N-terminal tagging method improved de novo sequencing of short peptides, enabling accurate characterization of peptides with four to ten amino acids.

• 4

  A preclinical fentanyl vaccine using a chemically distinct scaffold generated broadly cross-reactive antibodies and preserved ventilation in challenged mice.

• 5

  The modified fentanyl vaccine demonstrated potential for recognizing the entire fentanyl class, suggesting a proactive approach against emerging synthetic drugs.