5 Key Takeaways

• 1

  A draft plasma proteome atlas detected 179,049 potential proteoforms across 5,077 protein groups.

• 2

  Researchers classified 44,083 proteoforms from 2,089 protein groups as high confidence after detection in at least 3 of 4 replicate gel experiments.

• 3

  The median number of high-confidence proteoforms was 11 per protein, with the greatest diversity among abundant proteins and those involved in nutrient transport, clotting, and complement immunity.

• 4

  Olink and SomaScan measurements generally agreed more closely for abundant proteins with low or moderate proteoform diversity, while low concentrations often accompanied poor agreement.

• 5

  The atlas is an initial reference because most proteoforms were not fully identified, and low-abundance or disease-associated forms may be underrepresented.