Iodine in a pharmaceutical product applying Combustion IC with Inline Matrix Elimination

contributed by Metrohm | 09/17/2013

Iodine content in numerous iodinated X-ray contrast media (ICM) is approx. about 50% and is best determined by Combustion IC. For complete absorption of the iodine, high amounts of H2O2 (1000 mg/L) are required. Similarly, concentration of the internal standard should be 50 mg/L. The water content in the ICM is determined via Metrohm’s Karl Fischer oven method and has to be considered in the final calculation.

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