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Fields & Applications Liquid Chromatography, Pharma & Biopharma, Mass Spectrometry, Proteomics

Pushing the Limits of Liquid Chromatography

Expanding LC Boundaries

We must inspire creative minds to keep LC moving forward

By Mary J. Wirth, W. Brooks Fortune Distinguished Professor, Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Today, the pharmaceutical industry is a major user of liquid chromatography (LC), where stainless steel columns offer reproducibility and sensitive UV detection. The best commercially available LC columns for small-molecule separations now give about 50 percent more plates and faster separation times compared to 20 years ago. Even such a small improvement in resolution gained through the higher plate numbers is valuable for analysis of impurities and degradation products in pharmaceuticals – and the higher speed allows for faster methods development. Notably, separation speed has improved more than resolution.

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