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The Analytical Scientist / Issues / 2026 / February / Mass Spectrometry Takes on Amyloid
Clinical Mass Spectrometry

Mass Spectrometry Takes on Amyloid 

New guidelines target false negatives, Congo red variability, and the growing role of mass spectrometry in amyloid typing

By Jessica Allerton, James Strachan 02/18/2026 5 min read
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Top Institutions in Amyloidosis Diagnostics and Mass Spectrometry Proteomics

Leading institutions employ advanced mass spectrometry techniques such as LC-MS/MS for amyloid fibril typing, combined with rigorous pathology protocols and multidisciplinary clinical correlation. Their expertise includes developing and validating standardized diagnostic workflows, integrating proteomics with histopathology, and translating guidelines into clinical practice.

  • #1

    Mayo Clinic

    Rochester, MN

    Mayo Clinic is a global leader in amyloidosis research and diagnostics, pioneering the clinical application of mass spectrometry-based proteomics for amyloid typing and contributing extensively to consensus guidelines.

    Key Differentiators

    • Amyloidosis
    • Mass Spectrometry Proteomics
    • Pathology
  • #2

    Boston University Amyloidosis Center

    Boston, MA

    Boston University Amyloidosis Center integrates clinical care with cutting-edge proteomic research, focusing on improving diagnostic accuracy and therapeutic monitoring using mass spectrometry techniques.

    Key Differentiators

    • Amyloidosis
    • Proteomics
    • Clinical Pathology
  • #3

    University of Pittsburgh Medical Center (UPMC)

    Pittsburgh, PA

    UPMC has a strong program in amyloidosis diagnostics, utilizing mass spectrometry-based proteomics to enhance diagnostic precision and participating in research to refine biopsy interpretation criteria.

    Key Differentiators

    • Amyloidosis
    • Mass Spectrometry
    • Pathology
  • #4

    Brigham and Women's Hospital

    Boston, MA

    Brigham and Women's Hospital combines expertise in clinical pathology and proteomics, advancing the use of mass spectrometry in amyloid diagnostics and supporting guideline implementation.

    Key Differentiators

    • Amyloidosis
    • Proteomics
    • Pathology
  • #5

    Johns Hopkins University

    Baltimore, MD

    Johns Hopkins has a robust amyloidosis program integrating mass spectrometry proteomics with clinical pathology, contributing to research and education on amyloid detection and typing.

    Key Differentiators

    • Amyloidosis
    • Mass Spectrometry
    • Pathology

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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About the Author(s)

Jessica Allerton

Associate Editor, The Analytical Scientist

More Articles by Jessica Allerton

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at. From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

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