5 Key Takeaways

• 1

  Mammalian cells can directly produce several circulating indole and phenol metabolites previously attributed to the gut microbiome.

• 2

  Isotope tracing studies revealed that mammalian metabolism generates various aryl metabolites in physiologically relevant quantities.

• 3

  A novel TurboID platform allows tracing of secreted proteins back to specific cell types, revealing changes across metabolic states.

• 4

  Myc overexpression in cardiomyocytes shifts metabolic protein expression from fatty acid oxidation to glycolysis, indicating a pro-regenerative state.

• 5

  MALDI imaging distinguishes macrophage phenotypes, showing that M1 macrophages synthesize more phospholipids than M2 cells.