5 Key Takeaways

• 1

  A novel mass spectrometry imaging platform visualizes lipid metabolism at the single-cell level with ~800 nm resolution.

• 2

  The system allows researchers to investigate lipid reorganization during drug-induced apoptosis in HeLa and HepG2 cells.

• 3

  The study found dose- and time-dependent lipid remodeling, with structural phospholipids declining and energy-storage lipids mobilizing.

• 4

  Distinct lipid fingerprints were observed for different drugs, indicating varied mechanisms of action and cellular variability.

• 5

  The platform also successfully imaged lipid distributions in mouse brain tissue, suggesting broader applications in drug development.