The Tools of Proteomics
The proteome, which is the set of proteins expressed by a genome, cell, tissue or organism at a given time, presents immense analytical challenges – but offers substantial rewards. Here, current approaches to proteomics, their strengths and their shortcomings, are explored.
Norm Dovichi, Amanda Hummon |
Just as proteins are the third component in the flow of genetic information after DNA and RNA, so proteomics represents the third challenge temporally in the comprehensive analysis of living systems, after genomics and transcriptomics. It is also the most complex of these challenges. Proteins are much more diverse and difficult to quantitate than nucleic acids, and unlike DNA, their expression varies in both time and space.
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