Chiral separation of beta blocker pindolol enantiomers

contributed by YMC | 06/11/2015

Pindolol is a non-selective beta-blocker used for treatment of hypertension and angina pectoris. It is applied as a racemate, although only the (S)-form is the active stereoisomer.

YMC offers immobilised chiral phases that can be used either in normal or reversed phase mode as well as in SFC mode. CHIRAL ART Cellulose-SC is a very versatile phase to separate many chiral substances. YMC have developed two isocratic applications to separate the pindolol enantiomers in NP or RP mode. Both methods offer a high resolution. The NP application provides more potential for a preparative scale up, while the RP approach separates the enantiomers in a shorter time.

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