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Tosoh

Tosoh Bioscience is an acknowledged global leader in the field of liquid chromatography. For more than 25 years, we are providing cutting-edge solutions for customers developing and producing biologics, biosimilars or biobetters. Our product portfolio encompasses SEC instruments and a comprehensive line of media and (U)HPLC columns. Typical applications are the purification of therapeutic proteins in lab, pilot, and commercial scale, as well as their characterization or quality control by (U)HPLC.

Headquartered in Germany, Tosoh Bioscience's European operations offer extensive technical support. Tosoh Bioscience is part of the Tosoh Group that comprises over 100 companies worldwide and a workforce of more than 12000 people.

Contact Information:

Tosoh Bioscience GmbH

Im Leuschner Park 4

64347 Griesheim

Email: [email protected]

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Content by Tosoh:

Techniques & Tools Liquid Chromatography

Breaking Down the Complex Characterization Barrier

| Sam Dylan Moré | 6 min read

Polymeric drug delivery systems have enormous potential for personalized medicine, but their complexity create real characterization challenges

Techniques & Tools Liquid Chromatography

Four Become One: Simplifying mRNA Analysis

| Jonas Wege, Stephan Seiffert | 6 min read

A collaboration between Tosoh and Axolabs simplifies lipid nanoparticle mRNA vaccine analysis – condensing several techniques into a single method

Techniques & Tools Liquid Chromatography

Native LC-MS: From the Lab to the Manufacturing Floor

| Sponsored by Tosoh

What makes native LC-MS so powerful when it comes to biopharmaceutical analysis?

Fields & Applications Proteomics

Supporting a New Dawn in Biologic Therapies

| Sponsored by Tosoh

Explore all stages of therapeutic antibody development, from early research to method development, upscaling and production

Techniques & Tools Liquid Chromatography

Sugar Rush

| Sponsored by Tosoh

Tomasz Walski, Project Group Leader in the R&D department at Mabion S.A., tells us how he is keeping glycan analysis short and sweet.

Techniques & Tools Pharma & Biopharma

Toward Better Biotherapeutics

| Alexandre Goyon

The evolution of UHPLC, and how to streamline separations for complex biotherapeutics

Techniques & Tools Pharma & Biopharma

The Biopharma Multi-tool

| Judith Vajda

Size-exclusion chromatography – long a mainstay in routine biopharmaceutical analysis – receives an upgrade

Fields & Applications Pharma & Biopharma

UHP-SEC Analysis of Immunoglobulins with TSKgel UP-SW3000

| Sponsored by Tosoh

Antibody therapeutics are dominating the biopharmaceutical market. In 2013, six of the top ten global drug brands were monoclonal antibodies (mAbs).

Techniques & Tools Gas Chromatography

In Our Bodies

| Rich Whitworth, Stephanie Vine, Roisin McGuigan

We’ve shown that trained dogs can detect the presence of malignant ovarian cancer tumors using smell.

Fields & Applications Pharma & Biopharma

Fast Analysis of IgG Charge Heterogeneity by Ion Exchange Chromatography

| Sponsored by Tosoh

Evaluation of strong and weak cation exchange columns and dependence of separation on mobile phase pH

Safer AAV Analysis with Non-toxic AEX Method

| Contributed by Tosoh

The Cell and Gene Therapy industry relies heavily on Adeno-Associated Viruses (AAVs) as a therapeutic delivery platform

Analysis of plasmid topoisomers in 5 minutes

| Contributed by Tosoh

Recombinant plasmid DNA (pDNA) is increasingly used as a raw material in gene therapy and as an active ingredient for DNA vaccination.

Monitoring Structural Changes in Polysaccharides using SEC-MALS

| Contributed by Tosoh

SEC coupled with multi-angle light scattering (MALS) can determine structural changes in polysaccharides, with pullulans and dextrans as examples

Sensitive Quantification of AAVs and their Impurities

| Contributed by Tosoh

Size exclusion chromatography (SEC) coupled with multi-angle light scattering (MALS) is a powerful analytical method to quantify AAV capsid titers.

How a column facilitates SEC-MS

| Contributed by Tosoh

The TSKgel UP-SW3000-LS simplifies the combination of SEC analysis of biotherapeutics with Mmass spectrometry (MS) by delivering superior performance

Selecting the Optimal Column for Native SEC-MS of Monoclonal Antibodies

| Contributed by Tosoh

In this application note, a TSKgel UP-SW3000-LS column was coupled with an MS instrument for the analysis of a mAb standard.

Monitoring Structural Changes in Polysaccharides

| Contributed by Tosoh

Discover how the latest light scattering technology helps investigate and reveal differences in polymer architectures.

Characterization of MAbs Using FcR-Affinity and HILIC-MS

| Contributed by Tosoh

Combining FcR-IIIA affinity separation with HILIC-MS analysis allows rapid screening of antibodies

SEC-MALS for Antibody Therapeutics:

| Contributed by Tosoh

A Robust Method for In-Depth Sample Characterization.

Light Scattering for Determination of Molecular Weight and Radius of Gyration

| Contributed by Tosoh

Light scattering of macromolecules in solution has seen increasing interest over the past decades from scientists studying polymers and proteins.

Polymer Characterization with Triple-Detection GPC

| Contributed by Tosoh

The new LenS3 MALS-V dual detector is the only all-in-one detector for multi-angle light scattering (MALS) and viscometry for polymer characterization

A dedicated HIC column for ADC analysis

| Contributed by Tosoh

The TSKgel HIC-ADC Butyl column sets new standards in antibody-drug conjugates (ADC) DAR (drug-antibody ratio) analysis with unbeatable resolution

TSKgel UP-SW3000-LS – SEC columns for MALS and MS

| Contributed by Tosoh

TSKgel UP-SW3000-LS – Size exclusion UHPLC columns for light scattering and mass spectrometry

TSKgel UP-SW3000-LS – Size exclusion UHPLC columns for light scattering and mass spectrometry

| Contributed by Tosoh

Accurate and reproducible determination of molecular weight distribution of polyolefins

| Contributed by Tosoh

The EcoSEC High Temperature GPC system is a fully integrated and heated system with a unique dual flow RI detector.

TSKgel UP-SW series - Increased throughput and resolution for SEC analysis

| Contributed by Tosoh

Silica-based TSKgel UP-SW SEC columns are optimized for the UHPLC analysis of proteins.

LenS3 MALS Detector - A Revolutionary Approach to Light Scattering Technology

| Contributed by Tosoh

Multi-Angle Light Scattering has become the standard technique to determine molecular weight (MW) and size (radius of gyration) of macromolecules.

The EcoSEC Toolbox for SEC/GPC Analysis: Full Solution for Macromolecule Characterization

| Contributed by Tosoh

The all-in-one System delivers top performance, reliability and superior results.

HPLC affinity column for fast and accurate antibody titer analysis

| Contributed by Tosoh

TSKgel Size Exclusion Columns for UHPLC

| Contributed by Tosoh

Webinars on Demand

Fields & Applications Pharma & Biopharma

LenS3 – MALS Technology for Next Generation Biopharmaceuticals

| Sponsored by Tosoh

Multi-Angle Light Scattering (MALS) has become the standard technique to determine molecular weight (MW) and size (radius of gyration) of macromolecules.

Techniques & Tools Pharma & Biopharma

Fast and Furious – a Modern Way of assessing ADCC Activity

| Sponsored by Tosoh

This webinar will give an introduction to the principle of FcR affinity chromatography, the influence of Fc-glycans on the separation profile and potential applications.

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