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May 2014 Issue of The Analytical Scientist

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Articles featured in this issue

Fields & Applications Spectroscopy

Inspiration Particles, and Other Misconceptions

| Frank van Geel

Where does inspiration come from? I mean the insight that leads you to a new invention or that suddenly makes you aware of the solution to a problem?

Techniques & Tools Mass Spectrometry

Interred Tundra

| Rich Whitworth

Analysis of “dirty” ice from 3000 meters down reveals that ancient soil exists beneath the Greenland ice sheet

Techniques & Tools

Cutting that Red Tape

| Rich Whitworth

A report from the US National Science Board (NSB) has denounced excessive bureaucracy faced by researchers and urges a “focus on the science”

Techniques & Tools Mass Spectrometry

Nano-labels for “Sour” Oil

| Rich Whitworth

Carbon black nanoreporters can warn oil producers of unacceptable levels of hydrogen sulfide

Fields & Applications Genomics & DNA Analysis

Watson and Crick visit the local pub

| Nick Kim

Nick Kim gifts us with his very analytical and amusing view of the world around us.

Fields & Applications

For God’s Sake

| Rich Whitworth

Was an assistant analytical chemistry professor mistaken to instruct graduates not to “thank God”?

Fields & Applications

Learning Without Doing Equals Shortcoming

| Rich Whitworth

Removing practical assessments from science education is illogical, say UK chemical engineers

Techniques & Tools Mass Spectrometry

ASMS on Tour

| Rich Whitworth

On June 15, the 62nd ASMS Conference on Mass Spectrometry and Allied Topics sails into Baltimore

Fields & Applications Data Analysis

The Art of Analysis

| Rich Whitworth

In August, The Analytical Scientist will publish a special issue celebrating the very best images in the field of analytical science. And you have the chance to submit an image that defines your work.

Techniques & Tools Mass Spectrometry

My Ever-expanding Analytical Toolbox

| Hans-Gerd Janssen

New methods that focus on increased sensitivity or resolution are being developed on an almost daily basis. But are they the right methods and do we even need them? I say “no and no,” and here’s why.

Techniques & Tools Spectroscopy

Applying Infrared Spectroscopy at the Nanoscale

| Curtis Marcott, Craig Prater

How to meet today’s demands for nanoscale chemical analysis in materials and life sciences.

Fields & Applications Proteomics

Diving into Proper Proteomics

| Marcus Macht

Let’s not boast of “complete proteomes” or “protein coverage” until we correct our ignorance of post-translational modifications. Proteome analysis is more than just identifying and counting proteins.

Fields & Applications Genomics & DNA Analysis

Firearm Forensics

| Igor Lednev, Justin Bueno

Gun crime is not going away, but current forensic tools are limited at best. We believe that attenuated total reflectance (ATR) imaging could fill a big gap in the crime scene investigator’s armory.

Techniques & Tools Spectroscopy

Three Gurus of Spectroscopy

| Gary Hieftje, Peter Griffiths, Volker Deckert

What has driven spectroscopic techniques into their current prominent position in a plethora of application areas?

Techniques & Tools Pharma & Biopharma

Back to School for Pharmaceutical Analysis

| W. Franklin Smyth

Deeper consideration of individual analytical unit processes offers a more systematic approach to method development, ensuring that we don’t forget the basics in an increasingly sophisticated world.

Techniques & Tools Gas Chromatography

Fear and Loathing in Las Ciencias

| Lawrence “Larry” Mason

How broad are the legal duties of analytical laboratories and what do recent developments in US law mean for labs around the world?

Techniques & Tools Spectroscopy

A Little Respect

| Ellen Miseo

Sitting Down With Ellen Miseo, instrumentation and applications consultant for Analytical Answers and adjunct assistant professor at Bentley University, Massachusetts, USA.

Techniques & Tools Pharma & Biopharma

Rapid and Robust Subunit Domain Mapping of Monoclonal Antibody Based Biotherapeutics

Highly specific enzymes for middle down approach - rapid mass spectrometric analysis of antibody based biotherapeutics using FabRICATOR®

Fields & Applications Pharma & Biopharma

Two-dimensional Bioanalysis

| Pat Sandra, Koen Sandra, Gerd Vanhoenacker

In recent years, the top ten pharmaceuticals sales list has been extensively populated with protein therapeutics, such as monoclonal antibodies and recombinant proteins, that are used to treat various life-threatening diseases, including cancer and autoimmune diseases.

Techniques & Tools Gas Chromatography

Tea With… Luigi Mondello

| Rich Whitworth

What’s better than a nice cup of tea and a chat?

Fields & Applications Food, Beverage & Agriculture

Tea With… Chiara Cordero

| Rich Whitworth

For our second episode, we stay in Italy and speak with Chiara Cordero from the University of Turin

Techniques & Tools Gas Chromatography

Tea With… James Harynuk

| Rich Whitworth

Are mass spectral search libraries like crooked politicians? James Harynuk applies thermodynamic common sense to find the answer.

Fields & Applications Sample Preparation

When only a MALS detector will do…

Light scattering detectors play an important role in gel permeation chromatography and size exclusion chromatography (GPC/SEC) analysis because of their ability to directly measure molecular weight distribution. Multi angle light scattering (MALS) detectors are often chosen, in some instances because they provide the most accurate data for the measurement of the radius of gyration (Rg), and in others because they have become an accepted industry standard. The launch of Malvern Instruments’ new Viscotek SEC-MALS 20 detector extends commercial choice in this area and draws the technology into the spotlight.

Techniques & Tools Sample Preparation

Analysis of Membrane Protein by Multi-Detector SEC

Work performed in conjunction with the Membrane Protein Laboratory, Imperial College, London

Techniques & Tools Technology

Static Light Scattering Technologies for GPC/SEC Explained

| Sponsored by Malvern Panalytical

The aim of this guide is to provide the reader with a clear understanding of the different technological approaches used to measure molecular weight by static light scattering in a GPC/SEC experiment.

Techniques & Tools Sample Preparation

Characterization of Branded Co-Polymers by Triple Detection GPC

| Sponsored by Malvern Panalytical

Polymers can be loosely grouped into two structural categories – linear and branched.

Fields & Applications Data Analysis

The Zetasizer Nano - simple & versatile light scattering system

The Zetasizer Nano is the world's most widely used light scattering system, for measuring size, zeta potential and molecular weight. Applications range from characterizing high concentration colloids and nanoparticles, through to measurement of proteins and macromolecules in their native state, requiring as little as 12 microlitres of sample. The Zetasizer Nano can be used for the comprehensive characterization of proteins, colloids and nanoparticles, and is simple to use, highly sensitive, versatile and fast! This videos shows how quickly and easily a measurement can be made on the Zetasizer Nano.

Fields & Applications Sample Preparation

Overcoming the negative effect of protein structure on molecular weight measurement by Size Exclusion Chromatography

In this application note we will look at two examples where the retention volume of a sample could not be used to obtain an accurate measure of the sample MW. We will also describe the additional information that can be obtained using these advanced detectors. This work has been performed in conjunction with the Institut Pasteur, Paris, France

Fields & Applications Data Analysis

Protein analysis with the Zetasizer MicroV batch & flow mode

The Zetasizer µV (MicroV) is a dual purpose light scattering instrument designed specifically for the analysis of proteins. Firstly, it is a highly sensitive cuvette based dynamic light scattering instrument with the same great performance as the market leading Zetasizer Nano. Secondly, by simply changing the cell, it becomes an absolute molecular weight and size detector that can be added to any Size Exclusion Chromatography system (such as the Viscotek TDAmax).

Other issues of 2014