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The Analytical Scientist / Issues / 2026 / February / PFAS Bioaccumulation The Biology of Forever
Environmental Mass Spectrometry Trends Clinical

PFAS Bioaccumulation: The Biology of Forever

Carrie McDonough explores how PFAS move, bind, and transform within us – redefining what exposure really means

02/23/2026 13 min read
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5 Key Takeaways
  • 1

    PFAS compounds exhibit unique bioaccumulation behaviors that differ from traditional persistent organic pollutants.

  • 2

    Current risk assessment models fail to accurately represent PFAS interactions with proteins and lipids in the human body.

  • 3

    Carrie McDonough advocates for new models to assess long-term, low-level PFAS exposures from sources like drinking water.

  • 4

    Research on PFAS is rapidly evolving, with a significant focus on high-resolution mass spectrometry and toxicokinetics.

  • 5

    The unidentified organofluorine fraction in biological samples presents a major analytical challenge in PFAS research.

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.

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