Clinical Scorecard: Alzheimer’s in Full Flow

At a Glance

Key Highlights

• Cerebrovascular indicators align with established neuroimaging markers of Alzheimer’s pathology.
• Higher cerebrovascular responsiveness is associated with lower amyloid burden and larger hippocampal volume.
• Poorer cerebrovascular indicators are observed in participants with mild cognitive impairment or dementia.

Guideline-Based Recommendations

Diagnosis

• Monitor cerebrovascular signals using transcranial Doppler ultrasound and near-infrared spectroscopy.

Management

• Consider noninvasive cerebrovascular measurements as complementary to existing imaging approaches.

Monitoring & Follow-up

• Track cerebrovascular indicators over time to identify individuals at higher risk for cognitive decline.

Risks

• Declining vascular regulation may be part of the Alzheimer’s disease continuum.

Patient & Prescribing Data

Older adults, particularly those with cognitive impairments

Improving vascular health may slow or reduce Alzheimer’s-related brain changes.

Clinical Best Practices

• Utilize dynamic mathematical models to analyze cerebrovascular responses.
• Incorporate cerebrovascular measurements into routine assessments for Alzheimer’s risk.

References

• Mark and Mary Stevens Neuroimaging and Informatics Institute