Objective:

To investigate the relationship between cerebrovascular regulation and Alzheimer’s disease risk using noninvasive measurements.

Key Findings:

• Higher cerebrovascular indicators were associated with lower amyloid burden and larger hippocampal volume.
• Participants with mild cognitive impairment or dementia exhibited poorer cerebrovascular indicators compared to cognitively normal adults.
• Cerebrovascular measures align with MRI and PET scans used in Alzheimer’s research.

Interpretation:

Cerebrovascular regulation may play a critical role in brain health and Alzheimer's disease risk, suggesting that vascular health could be a target for early intervention.

Limitations:

• The study is cross-sectional, providing only a snapshot of the relationships.
• Further research is needed to determine if vascular signals can predict future cognitive decline.

Conclusion:

Noninvasive cerebrovascular measurements could complement existing imaging approaches and help identify individuals at higher risk for Alzheimer's disease.