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Invention, Research & Application of Intact & Native Mass Spectrometry for Biopharmaceuticals
Protein characterization is required at all stages of the biopharmaceutical pipeline, and mass spectrometry plays a key part in enabling confident structural insight into these complex molecules. Join us on a journey of biopharmaceutical mass analysis, and learn from recognized leaders in academia and industry about LC-MS analysis of therapeutic proteins – including Prof. Alexander Makarov, Dr. David Tickle and Prof. Dame Carol Robinson.
Thursday 26th October 2017, 0730 PDT - Now On Demand
Thursday 30 November 2017, 0730 PST
Tuesday 5 December 2017, 0730 PST
Principles of Charged Aerosol Detector Method Development – from Simple Isocratic to Complex 2D Chromatographic Approaches
The Charged Aerosol Detector (CAD) and related techniques (e.g., evaporative light scattering detectors) have a nearly identical detection scope and the same eluent requirements. However, key differences in the downstream aerosol measurement technique, result in differences in the shape of the response curves, peak shape, sensitivity limits, and uniformity of response. The Thermo Scientific™ Charged Aerosol Detectors deliver flexibility, performance and ease-of-use for all labs to advance your work, where other systems fail to perform.
Best practices for efficient method development and transfer, and for routine use of CAD are outlined in the first part of this webinar.
In the second part, the development of two 2D-LC approaches using CAD and MS are described in detail for determining the heterogeneity and stability of polysorbates in MAb products.
Tuesday 28th November 2017, 3pm GMT
Extend your application reach with new technology advances in supercritical fluid chromatography (SFC)
Modern ultrafast SFC is a powerful separation mechanism with an extended application reach. Whether you are new to SFC or a long-time user, join Terry A. Berger to learn how to achieve highest injection linearity and precision, increased separation speed and throughput, and improved signal-to-noise.
Wednesday 29th November 2017, 16:00 GMT / 11:00 EST / 08:00 PST / 17:00 CET