Objective:

To analyze how genetic background and environment shape human biology through a multiomics survey of healthy adults across different ancestry groups and continents.

Key Findings:

• Ethnicity showed strong associations with immune, metabolic, pathogen, and microbiome features.
• South Asian participants had higher pathogen-reactive antibody signatures.
• Individuals of European ancestry exhibited greater gut microbial diversity and elevated levels of lipid and metabolite classes linked to cardiovascular and metabolic risk.
• Geography influenced molecular and microbial profiles, with shifts in cholesterol, bile acid, and arachidonic acid pathways observed in participants living outside their ancestral regions.
• Biological age varied by geography, with East Asian participants showing lower biological age in East Asia and European ancestry participants showing lower biological age in the US and Canada.

Interpretation:

The study provides an open-access dataset that enhances understanding of how molecular and microbial baselines differ across populations, potentially refining precision medicine.

Limitations:

Conclusion:

The resulting dataset offers a comprehensive resource for studying human molecular diversity and its implications for health.