SCIEX

A rapid, robust, sensitive and specific LC-MS/MS assay using the AB SCIEX QTRAP® 6500 system has been developed for the simultaneous detection of all major forms of vitamin B complex. The method detects all currently used forms of vitamin B6 and vitamin B3 in infant formula and includes vitamin B12.

The accidental or fraudulent blending of meat and animal products from different species is highly relevant for consumers with ethical concerns against eating species such as horse or pork in particular the Jewish and Muslim communities.

Increasing selectivity with high-resolution multiple reaction monitoring (MRMHR) improves the signal-to-noise ratio for better accuracy, dynamic range, and LLOQ when quantitating isobaric prostaglandin-D2α isoforms

Using SelexION™ Differential Mobility Separation Technology for better selectivity for peptides in complex mixtures on the AB SCIEX Triple Quad™ 5500 LC/MS/MS System

The high resolution and accurate mass AB SCIEX TripleTOF™ 4600 LC/MS/MS system was used to screen for drugs from forensic equine urine, and to quantify drug compounds with excellent accuracy and high reproducibility. Fast Information Dependent Acquisition (IDA) MS/MS spectra were used to additionally confirm the identity of detected compounds based on mass spectral library searching.

This application note describes a novel screening method for major metabolites of two main active ingredients of K2: JWH-018 and JWH-073.

The high resolution and accurate mass AB SCIEX TripleTOF™ 5600 LC/MS/MS system was used to screen for drugs from both forensic equine and forensic toxicology urine, and to quantify drug compounds with excellent accuracy and high reproducibility. Fast Information Dependent Acquisition (IDA) MS/MS spectra were used to additionally confirm the identity of detected compounds based on mass spectral library searching. The acquired full scan MS and MS/MS data can further be used to retrospectively mine data to identify non-targeted and unexpected compounds. An example is also given to demonstrate true unknown screening by the identification of the contents of an unknown pill. PeakView™ software with the XIC Manager add-in was used for targeted and non-targeted data processing. The XIC Manger consists of a table for defining a list of masses or formula to generate extracted ion chromatograms (XIC), and the ability to review results is based upon retention times, accurate mass, isotopic pattern and MS/MS library searching.