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Tosoh

Application Notes by Tosoh

Correlation of FcR Affinity Chromatography with Glycan Pattern and ADCC Activity of a Therapeutic Antibody

| Contributed by Tosoh

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MoA) of monoclonal antibodies used in cancer treatment.

Evaluation of mAb ADCC Activity through Fc Receptor Affinity Chromatography

| Contributed by Tosoh

Antibody-dependent cell-mediated cytotoxicity is a mechanism of action of anti-tumor antibodies in which the Fcy receptor (FcR) plays a key role.

Determination of the Molar Mass Distribution of Phenol-Formaldehyde Resins Using GPC

| Contributed by Tosoh

Phenol formaldehyde resins (PFRs) are condensation polymers and are obtained by condensing phenol with formaldehyde in the presence of an acidic or alkaline catalyst.

UHP-SEC Analysis of Biosimilars Using Size Exclusion Chromatography

| Contributed by Tosoh

The amounts of high and low molecular weight impurities are critical quality attributes for a therapeutic protein.

SEC/MS Analysis of a Bispecific Antibody

| Contributed by Tosoh

More potent formats of monoclonal antibodies (mAbs), such as bispecific antibodies (bsAbs), are on the rise in the area of biotherapeutics.

Fields & Applications Pharma & Biopharma

Analysis of mAb aggregates by SE-UHPLC

| Contributed by Tosoh

Learn how to apply SEC technology most efficiently to establish a fast, highly reproducible, and accurate SE-UHPLC method for mAb aggregate analysis.

Fields & Applications Pharma & Biopharma

Increased Monoclonal Antibody Resolution in UHPLC

| Contributed by Tosoh

With the introduction of TSKgel UP-SW3000 silica-based UHPLC columns increased speed and higher resolution can be achieved for the separation of antibody fragments, monomers, and dimers.

Fields & Applications Pharma & Biopharma

DAR Analysis of Antibody-Drug Conjugates

| Contributed by Tosoh

An Antibody-Drug Conjugate (ADC) was analyzed using a TSKgel® Butyl-NPR column, the least hydrophobic of the TSKgel HIC columns

DAR Analysis of Antibody Drug Conjugates (ADC)

| Contributed by Tosoh

Antibody-drug conjugates (ADCs) represent some of the most promising next-generation biopharmaceuticals.

Analysis of Monoclonal Antibody and Protein Aggregates Induced by Denaturation using a Novel SEC Column

| Contributed by Tosoh

This application note will show the superior resolving power of the TSKgel UltraSW Aggregate column for the analysis of monoclonal antibody and metalloprotein aggregates formed under forced denatured conditions.

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