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Welcome to our 100th issue – and the Top 100 performers in analytical science! As part of the celebrations, you’ll find a “joint” In My View from 15 of this year’s Power Listers, who reveal the single biggest challenge facing the field; our science slam, featuring early career researchers and their “elevator pitches;” as well as the Power List itself: find out what this year’s nominees had to say about instruments they couldn’t live without, their heroes and what they might be doing in another life. Last but not least, we Sit Down With Matthias Mann, “The Proteomics Ethicist.”

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