Fields & Applications Pharma & Biopharma, Liquid Chromatography, Mass Spectrometry, Technology

Characterizing Antibody-Drug Conjugates Using Micro Pillar Array Columns Combined with Mass Spectrometry (μPAC™-MS)

contributed by Pharma Fluidics | 11/07/2017

The use of micro pillar array columns (μPAC™) for characterizing antibody-drug-conjugates is presented. Kadcyla^® (ado-trastuzumab emtansine) and, for comparison, Herceptin^® (trastuzumab) tryptic digests were analyzed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).

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