Fields & Applications Pharma & Biopharma, Mass Spectrometry

An approach to streamline and simplify the identification of crucial metabolites from targeted protein degraders

07/31/2024

sponsored by SCIEX

The identification of drug metabolites is a critical step in drug development due to their impact on drug efficacy and safety. LC-MS platforms provide good selectivity and sensitivity making it the preferred technique for metabolite identification. Here, metabolite identification was performed using unique fragments from EAD and CID spectra. Fragment information from EAD and CID spectra were processed in a single result file to achieve confident structure assignment of and localization of metabolites.

Webinar Learning Objectives:

Options to achieve more accurate structure assignments to gain a competitive edge in identifying drug metabolites
How to enhance signal sensitivity for confident metabolite identification with Zeno trap technology
Learn about a streamlined path from data acquisition to processing for metabolite identification using Molecule Profiler software

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